Abstract
Can a minor difference in the nonmetal binding sequence of antimicrobial clavanins explain the drastic change in the coordination environment and antimicrobial efficiency? This study answers the question with a definite "yes", showing the details of the bioinorganic chemistry of Zn(II) and Cu(II) complexes with clavanins, histidine-rich, antimicrobial peptides from hemocytes of the tunicate Styela clava.
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / toxicity
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Bacteria / drug effects
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Blood Proteins / chemistry
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Blood Proteins / pharmacology*
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Blood Proteins / toxicity
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Candida albicans / drug effects
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Cell Line
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Coordination Complexes / toxicity
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Copper / chemistry
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Humans
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Microbial Sensitivity Tests
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Zinc / chemistry
Substances
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Anti-Bacterial Agents
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Blood Proteins
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Coordination Complexes
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Copper
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Zinc