MiRNA-Wnt signaling regulatory network in colorectal cancer

J Biochem Mol Toxicol. 2021 Oct;35(10):e22883. doi: 10.1002/jbt.22883. Epub 2021 Aug 12.

Abstract

Colorectal cancer (CRC) is one of the common malignancies worldwide and the Wnt signaling pathway is recognized as the main disrupted pathway in this malignancy. MicroRNAs (miRNAs) are recognized to contribute to the pathogenesis of CRC by triggering or impeding the Wnt signaling pathway. In addition, transcriptional regulation of miRNAs by canonical Wnt signaling also participates in CRC cell progression. In this review, we present comprehensive literature of the existing data on the interaction of miRNAs and Wnt signaling that could be useful in future studies in the field of CRC management.

Keywords: Wnt signaling; cancer management; colorectal cancer; mcroRNA.

Publication types

  • Review

MeSH terms

  • Carcinogenesis / genetics
  • Carcinogenesis / metabolism
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / metabolism*
  • Gene Expression Regulation, Neoplastic
  • Gene Regulatory Networks
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Wnt Proteins / genetics
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway / genetics*
  • beta Catenin / genetics
  • beta Catenin / metabolism*

Substances

  • CTNNB1 protein, human
  • MicroRNAs
  • Wnt Proteins
  • beta Catenin