Objectives: The mouth restriction of patients with oral submucous fibrosis (OSF) seriously affects their eating food and the quality of life. There are few reports about improving the oral opening degree in patients with OSF. This study aims to explore the effect of oral opening training on the improvement of mouth opening limitation in patients with OSF treated with local injection.
Methods: A total of 220 outpatients with limited mouth opening of OSF were collected from the Center of Stomatology, Xiangya Hospital, Central South University, and randomly divided into a control group and an experiment group (n=110). The control group were treated with local injection of Salvia miltiorrhiza and triamcinolone acetonide, once a week, and 8 times a course. The experimental group were treated with local injection combined with mouth opening training for 2 years. The degree of mouth opening was compared between the 2 groups at the end of local injection treatment, 1 year and 2 years after the treatment. The curative effect was evaluated according to the size of the opening, the lamellar structure of the mucosa, and the condition of the cords.
Results: A total of 197 patients completed the whole course of treatment, with 107 in the experimental group and 90 in the control group. At the end of treatment, 1 year and 2 years after the treatment, the degree of mouth opening in the experimental group was (36.14±2.62), (39.67±2.67), and (39.80±2.57) mm, respectively, which was significantly higher than that in the control group (24.71±1.97), (22.82±2.13), and (22.02±2.09) mm, respectively. The difference was significant (P<0.05). The increase of mouth opening in the experimental group was significantly better than that in the control group. Two years after local injection treatment, the effective rate of the experimental group was 97.1%, which was significantly higher than that of the control group (47.8%, P<0.05).
Conclusions: Mouth opening training can significantly increase the degree of mouth opening in patients with OSF treated with local injection.
目的: 口腔黏膜下纤维性变(oral submucous fibrosis，OSF)患者张口受限严重影响其进食和生活质量，目前国内外关于改善OSF患者张口度的文献鲜有报道。本研究探讨张口训练对局部注射治疗OSF患者张口度的影响。方法: 收集中南大学湘雅医院口腔医学中心220例OSF张口受限的门诊患者，随机分为对照组和实验组，每组110例。对照组采用丹参联合曲安奈德局部注射治疗，每周1次，8次为一疗程；实验组在对照组的基础上联合张口训练2年。比较两组患者局部注射治疗结束时、治疗结束后1年和2年的张口度。根据开口度大小、黏膜板状结构和条索情况评估疗效。结果: 完成治疗全过程的患者197例，其中实验组107例，对照组90例。实验组张口度在局部注射治疗结束时、治疗结束后1年和2年分别为(36.14±2.62)，(39.67±2.67)和(39.80±2.57) mm，均明显大于对照组的(24.71±1.97)，(22.82±2.13)和(22.02±2.09) mm(均P<0.05)。局部注射治疗结束2年复诊时，实验组有效率为97.1%，明显高于对照组的47.8%(P<0.05)。结论: 张口训练能显著增加局部注射治疗OSF患者的张口度。.
Keywords: mouth opening; oral opening training; oral submucous fibrosis.