Pyroptosis, a New Breakthrough in Cancer Treatment

Dengqiang Wu; Changhong Wei; Yujie Li; Xuejia Yang; Sufang Zhou

doi:10.3389/fonc.2021.698811

Pyroptosis, a New Breakthrough in Cancer Treatment

Front Oncol. 2021 Jul 26:11:698811. doi: 10.3389/fonc.2021.698811. eCollection 2021.

Authors

Dengqiang Wu¹, Changhong Wei¹, Yujie Li², Xuejia Yang¹, Sufang Zhou^{1

2}

Affiliations

¹ National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, China.
² Department of Biochemistry and Molecular Biology, School of Pre-Clinical Science, Guangxi Medical University, Nanning, China.

Abstract

The way of cell death can be roughly divided into two categories: cell necrosis and PCD(programmed cell death). Pyroptosis is a kind of PCD, its occurrence depends on the gasdermin protein family and it will produce inflammatory response. With constant research in recent years, more and more evidences show that pyroptosis is closely related to the occurrence and development of tumors. The treatment of tumors is a big problem worldwide. We focus on whether we can discover new potential tumor markers and new therapeutic targets from the mechanism. If we can understand the mechanism of pyroptosis and clear the relationship between pyroptosis and the development of tumors, this may provide a new reference for clinical cancer treatment.

Keywords: antitumor immunity; cancer treatment; gasdermin family; programmed cell death; pyroptosis.

Publication types

Review