Culture-negative chronic hematogenous osteomyelitis in a two months old girl: a case report

BMC Musculoskelet Disord. 2021 Aug 11;22(1):679. doi: 10.1186/s12891-021-04547-4.

Abstract

Background: Previous articles have focused on the diagnosis and treatment of acute hematogenous osteomyelitis. Here, we present a case of chronic hematogenous osteomyelitis in a 2-month-old girl. The diagnostic procedure was unusual and difficult due to negative culture results.

Case presentation: A girl aged 2 months and 23 days had fever and swelling in her right lower leg for 7 days. On the basis of her medical history, physical, and histological examination results; and radiologic and magnetic resonance imaging findings, a diagnosis of chronic osteomyelitis was made. The patient underwent surgical treatment and was discharged successfully. The patient showed good recovery and no sequelae at the 12-month follow-up.

Conclusion: Hematogenous osteomyelitis in babyhood is different from that at any other age. Hematogenous osteomyelitis-related bone destruction in babyhood is more serious and occurs faster. The transition from acute hematogenous osteomyelitis to chronic hematogenous osteomyelitis takes only 7 days. To the best of our knowledge, this chronic hematogenous osteomyelitis patient is the youngest ever reported.

Keywords: Case report; Children; Chronic hematogenous osteomyelitis; Culture-negative; Infection; Pediatric.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Female
  • Humans
  • Infant
  • Leg
  • Magnetic Resonance Imaging
  • Osteomyelitis* / diagnostic imaging
  • Osteomyelitis* / therapy