Application Prospects and Prospect of Metabolomics in the Identification of Sudden Cardiac Death

Fa Yi Xue Za Zhi. 2021 Jun;37(3):388-395. doi: 10.12116/j.issn.1004-5619.2019.491116.
[Article in English, Chinese]

Abstract

In cases of sudden death, the prevention of sudden cardiac death and the analysis of the cause of death after sudden cardiac death have always been a difficult problem. Therefore, clinical research and forensic pathological identification of sudden cardiac death are of great significance. In recent years, metabolomics has gradually developed into a popular field of life science research. The detection of "metabolic fingerprints" of biological fluids can provide an important basis for early diagnosis of diseases and the discovery of potential biomarkers. This article reviews the current research status of sudden cardiac death and the research on metabolomics of cardiovascular diseases that is closely related to sudden cardiac death and analyzes the application prospects of metabolomics in the identification of the cause of sudden cardiac death.

题目: 代谢组学在心脏性猝死鉴定中的应用前景及展望.

摘要: 在猝死案例中,心脏性猝死的预防及猝死发生后死因鉴定一直是难点问题。因此,心脏性猝死的临床研究和法医病理学鉴定具有重要意义。近年来,代谢组学逐渐发展成为生命科学研究的热门领域,检测生物体液的“代谢指纹”可以为疾病早期诊断、潜在生物标志物的发掘等提供重要依据。本文就心脏性猝死的研究现状以及与心脏性猝死密切相关的心血管疾病代谢组学方面的研究做一综述,分析代谢组学在心脏性猝死鉴定中的应用前景。.

关键词: 法医病理学;代谢组学;心脏性猝死;综述.

Keywords: forensic pathology; metabolomics; sudden cardiac death; review.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Death, Sudden, Cardiac* / etiology
  • Death, Sudden, Cardiac* / prevention & control
  • Forensic Pathology
  • Humans
  • Metabolomics*

Substances

  • Biomarkers