Sonodynamic therapy (SDT) is a fast-growing therapy activated by using ultrasound to initiate a catalytic reaction of sensitizing agents and kill tumor cells through producing reactive oxygen species (ROS). Both sinoporphyrin sodium (DVDMS) and IR780 are preeminent sonosensitizers and have been used in SDT alone. In this study, tumor targeting multifunctional composite nanoparticles (DVDMS@IR780@PFP@PLGA, DIPP-NPs) were synthesized by encapsulating DVDMS, IR780 and perfluoropentane (PFP) to synergistically enhance SDT and achieve imaging of tumors. The loaded IR780 is regarded as a "navigator" to accurately identify and target tumor cells/tissues. DVDMS and IR780 not only can realize the directed SDT, but also can perform photoacoustic (PA) imaging. PFP plays its role in enhancing the ultrasound (US) imaging. Generally, DIPP-NPs not only have an obvious synergistic anti-tumor effect, but also are able to carry out dual-mode imaging, which paves a promising way for tumor therapy.