Transmission of SARS-CoV-2 Alpha Variant (B.1.1.7) From a BNT162b2-Vaccinated Individual

Solen Kernéis; Delphine Planas; Sandrine Imbeaud; Isabelle Staropoli; Julien Puech; Nicolas Robillard; Julien Rodary; Timothée Bruel; Thomas Vieillard; Olivier Schwartz; Laurent Belec; Hélène Péré; David Veyer

doi:10.1093/ofid/ofab369

Transmission of SARS-CoV-2 Alpha Variant (B.1.1.7) From a BNT162b2-Vaccinated Individual

Open Forum Infect Dis. 2021 Jul 20;8(8):ofab369. doi: 10.1093/ofid/ofab369. eCollection 2021 Aug.

Authors

Solen Kernéis^{1

2}, Delphine Planas^{3

4}, Sandrine Imbeaud⁵, Isabelle Staropoli^{3

4}, Julien Puech⁶, Nicolas Robillard⁶, Julien Rodary⁶, Timothée Bruel^{3

4}, Thomas Vieillard⁷, Olivier Schwartz^{3

4}, Laurent Belec^{6

8

9}, Hélène Péré⁵, David Veyer^{5

6}

Affiliations

¹ Equipe de Prévention du Risque Infectieux, AP-HP, Hôpital Bichat, Paris, France.
² Université de Paris, INSERM, IAME, Paris, France.
³ Virus & Immunity Unit, Department of Virology, Institut Pasteur, CNRS UMR3569, Paris, France.
⁴ Vaccine Research Institute, Faculté de Médecine, INSERM U955, Université Paris-Est Créteil , Créteil, France.
⁵ Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM U1138, Paris, France.
⁶ Laboratoire de Virologie, Service de Microbiologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁷ Laboratoire Biosmose-idf, Rueil-Malmaison, France.
⁸ INSERM U970, PARCC, Hôpital Européen Georges Pompidou, Faculté de Médecine, Université de Paris, Paris, France.
⁹ Faculté de Médecine, Université de Paris, Paris, France.

Abstract

Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) acquisition after vaccination with BNT162b2 have been described, but the risk of secondary transmission from fully vaccinated individuals remains ill defined. Herein we report a confirmed transmission of SARS-CoV-2 alpha variant (B.1.1.7) from a symptomatic immunocompetent woman 4 weeks after her second dose of BNT162b2, despite antispike seroconversion.

Keywords: BNT162b2; SARS-CoV-2; transmission; vaccination.