What We Learned in 25 Years of Interactive Molecular Design Sessions

ChemMedChem. 2021 Sep 16;16(18):2760-2763. doi: 10.1002/cmdc.202100351. Epub 2021 Aug 10.

Abstract

We retrace Prof. François Diederich's consultancy work for Roche and its impact over the years he worked with us. François Diederich uniquely shaped our approach to molecular design, and interactions with him and his research group at ETH Zurich have created deep insights into molecular recognition. Herein we share how his style and approach continue to inspire us.

Keywords: drug discovery; knowledge generation; molecular design; molecular recognition.

Publication types

  • Review

MeSH terms

  • Cysteine Endopeptidases / chemical synthesis*
  • Cysteine Endopeptidases / chemistry
  • Humans
  • Macrocyclic Compounds / chemical synthesis*
  • Macrocyclic Compounds / chemistry
  • Molecular Structure

Substances

  • Macrocyclic Compounds
  • Cysteine Endopeptidases
  • rhodesain