Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Zhennan Shi; Nathchar Naowarojna; Zijian Pan; Yilong Zou

doi:10.1038/s41467-021-25159-5

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Nat Commun. 2021 Aug 9;12(1):4792. doi: 10.1038/s41467-021-25159-5.

Authors

Zhennan Shi^#^{1

2

3}, Nathchar Naowarojna^#^{1

2

3}, Zijian Pan^{2

3}, Yilong Zou^{4

5

6}

Affiliations

¹ Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
² School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
³ Institute of Biology, Westlake Institute of Advanced Studies, Hangzhou, Zhejiang, China.
⁴ Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China. zouyilong@westlake.edu.cn.
⁵ School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. zouyilong@westlake.edu.cn.
⁶ Institute of Biology, Westlake Institute of Advanced Studies, Hangzhou, Zhejiang, China. zouyilong@westlake.edu.cn.

^# Contributed equally.

Abstract

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Line, Tumor
Cystine
Ferroptosis*
Glutathione
Humans

Substances

Cystine
Glutathione