Molecular Pathology of Mature Lymphoid Malignancies

Abstract

Lymphoid malignancies are a broad and heterogeneous group of neoplasms. In the past decade, the genetic landscape of these tumors has been explored and cataloged in fine detail offering a glimpse into the mechanisms of lymphomagenesis and new opportunities to translate these findings into patient management. A myriad of studies have demonstrated both distinctive and overlapping molecular and chromosomal abnormalities that have influenced the diagnosis and classification of lymphoma, disease prognosis, and treatment selection.

Keywords: B-cell lymphoma; Fluorescence in situ hybridization; Hodgkin lymphoma; Molecular pathology; Next generation sequencing; T-cell lymphoma.