Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers

Qian Lu; Jun Lou; Ruyun Cai; Weidong Han; Hongming Pan

doi:10.1186/s12935-021-02123-3

Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers

Cancer Cell Int. 2021 Aug 9;21(1):417. doi: 10.1186/s12935-021-02123-3.

Authors

Qian Lu¹, Jun Lou¹, Ruyun Cai², Weidong Han³, Hongming Pan⁴

Affiliations

¹ Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
² Department of Colorectal Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
³ Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China. hanwd@zju.edu.cn.
⁴ Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China. panhongming@zju.edu.cn.

Abstract

Long non-coding RNAs refer to transcripts over 200 nt in length that lack the ability to encode proteins, which occupy the majority of the genome and play a crucial role in the occurrence and development of human diseases, especially cancers. SBF2-AS1, a newly identified long non-coding RNA, has been verified to be highly expressed in diversiform cancers, and is involved in processes promoting tumorigenesis, tumor progression and tumor metastasis. Moreover, upregulation of SBF2-AS1 expression was significantly related to disadvantageous clinicopathologic characteristics and indicated poor prognosis. In this review, we comprehensively summarize the up-to-date knowledge of the detailed mechanisms and underlying functions of SBF2-AS1 in diverse cancer types, highlighting the potential of SBF2-AS1 as a diagnostic and prognostic biomarker and even a therapeutic target.

Keywords: Biomarker; Cancers; LncRNA; Molecular mechanism; SBF2-AS1; Therapy target.

Publication types

Review