Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls

Jikang Shi; Siyu Liu; Yanbo Guo; Sainan Liu; Jiayi Xu; Lingfeng Pan; Yueyang Hu; Yawen Liu; Yi Cheng

doi:10.1186/s12872-021-02192-2

Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls

BMC Cardiovasc Disord. 2021 Aug 9;21(1):385. doi: 10.1186/s12872-021-02192-2.

Authors

Jikang Shi¹, Siyu Liu¹, Yanbo Guo¹, Sainan Liu¹, Jiayi Xu¹, Lingfeng Pan¹, Yueyang Hu², Yawen Liu³, Yi Cheng⁴

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
² Department of Children and Adolescence Health, School of Public Health, Jilin University, Changchun, 130021, Jilin, China.
³ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China. ywliu@jlu.edu.cn.
⁴ The Cardiovascular Center, The First Hospital of Jilin University, Changchun, 130021, China. chengyi@jlu.edu.cn.

Abstract

Background: Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension.

Methods: Case-control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database according to PRISMA guideline. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models.

Results: A total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR = 1.44, 95% CI 1.26-1.63; GT vs GG: OR 1.34, 95% CI 1.18-1.52; TT vs GG: OR 1.80, 95% CI 1.41-2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25-1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35-2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11-1.40).

Conclusions: We found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene-gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension.

Keywords: Hypertension; Meta-analysis; Polymorphism; eNOS; rs1799983.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Case-Control Studies
Confidence Intervals
Data Analysis
Essential Hypertension / ethnology
Essential Hypertension / genetics*
Gene-Environment Interaction
Humans
Models, Genetic
Nitric Oxide Synthase Type III / genetics*
Odds Ratio
Polymorphism, Single Nucleotide*
Publication Bias

Substances

NOS3 protein, human
Nitric Oxide Synthase Type III