Rodent-Borne Orthohantaviruses in Vietnam, Madagascar and Japan

Fuka Kikuchi; Kae Senoo; Satoru Arai; Kimiyuki Tsuchiya; Nguyễn Trường Sơn; Masaharu Motokawa; Marie Claudine Ranorosoa; Saw Bawm; Kyaw San Lin; Hitoshi Suzuki; Akira Unno; Keisuke Nakata; Masashi Harada; Keiko Tanaka-Taya; Shigeru Morikawa; Motoi Suzuki; Tetsuya Mizutani; Richard Yanagihara

doi:10.3390/v13071343

Rodent-Borne Orthohantaviruses in Vietnam, Madagascar and Japan

Viruses. 2021 Jul 12;13(7):1343. doi: 10.3390/v13071343.

Authors

Fuka Kikuchi^{1

2}, Kae Senoo^{2

3}, Satoru Arai², Kimiyuki Tsuchiya⁴, Nguyễn Trường Sơn^{5

6}, Masaharu Motokawa⁷, Marie Claudine Ranorosoa⁸, Saw Bawm⁹, Kyaw San Lin¹⁰, Hitoshi Suzuki¹¹, Akira Unno¹², Keisuke Nakata¹², Masashi Harada¹³, Keiko Tanaka-Taya², Shigeru Morikawa¹⁴, Motoi Suzuki², Tetsuya Mizutani¹, Richard Yanagihara¹⁵

Affiliations

¹ Center for Infectious Disease Epidemiology and Prevention Research, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8538, Japan.
² Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
³ Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan.
⁴ Laboratory of Bioresources, Applied Biology Co., Ltd., Tokyo 107-0062, Japan.
⁵ Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam.
⁶ Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam.
⁷ The Kyoto University Museum, Kyoto University, Kyoto 606-8501, Japan.
⁸ Mention Foresterie et Environnement, Ecole Supérieur des Sciences Agronomiques, Université d'Antananarivo, Antananarivo 101, Madagascar.
⁹ Department of Pharmacology and Parasitology, University of Veterinary Science, Nay Pyi Taw 15013, Myanmar.
¹⁰ Department of Aquaculture and Aquatic Disease, University of Veterinary Science, Nay Pyi Taw 15013, Myanmar.
¹¹ Laboratory of Ecology and Genetics, Graduate School of Environmental Science, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan.
¹² Local Independent Administrative Agency Hokkaido Research Organization, Bibai 079-0198, Japan.
¹³ Laboratory Animal Center, Osaka City University, Sumiyoshi, Osaka 545-8585, Japan.
¹⁴ Department of Microbiology, Faculty of Veterinary Medicine, Okayama University of Science, Imabari 794-8555, Japan.
¹⁵ Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.

Abstract

Hantaviruses are harbored by multiple small mammal species in Asia, Europe, Africa, and the Americas. To ascertain the geographic distribution and virus-host relationships of rodent-borne hantaviruses in Japan, Vietnam, Myanmar, and Madagascar, RNAlater™-preserved lung tissues of 981 rodents representing 40 species, collected in 2011-2017, were analyzed for hantavirus RNA by RT-PCR. Our data showed Hantaan orthohantavirus Da Bie Shan strain in the Chinese white-bellied rat (Niviventer confucianus) in Vietnam, Thailand; orthohantavirus Anjo strain in the black rat (Rattus rattus) in Madagascar; and Puumala orthohantavirus Hokkaido strain in the grey-sided vole (Myodes rufocanus) in Japan. The Hokkaido strain of Puumala virus was also detected in the large Japanese field mouse (Apodemus speciosus) and small Japanese field mouse (Apodemus argenteus), with evidence of host-switching as determined by co-phylogeny mapping.

Keywords: Hantaan orthohantavirus; Puumala orthohantavirus; Thailand orthohantavirus; rodents; spill-over infection.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arvicolinae / virology
Hantavirus Infections / epidemiology*
Hantavirus Infections / veterinary
Hantavirus Infections / virology
Japan
Madagascar
Mice
Murinae / virology
Orthohantavirus / pathogenicity
Phylogeny
Puumala virus / pathogenicity
Rats
Rodentia / virology
Vietnam

Abstract

Publication types

MeSH terms

Grants and funding