Combination treatment with monoclonal antibodies: Secukinumab, benralizumab and dupilumab for the combined management of psoriasis and severe asthma

Australas J Dermatol. 2021 Nov;62(4):506-508. doi: 10.1111/ajd.13676. Epub 2021 Aug 9.

Abstract

Biological disease-modifying agents have increasingly become available for the effective treatment of both cutaneous and non-cutaneous inflammatory conditions. We report a case of a woman treated successfully for psoriasis and psoriatic arthritis with the IL-17 inhibitor secukinumab whilst simultaneously being treated for severe asthma and nasal polyps, initially with the IL-5 inhibitor benralizumab, followed by dupilumab, a monoclonal antibody that targets the IL-4 receptor alpha subunit which blocks signalling from both IL-4 and IL-13.

Keywords: asthma; biologics; nasal polyps; psoriasis; psoriatic arthritis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Asthmatic Agents / therapeutic use*
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Asthma / complications
  • Asthma / drug therapy*
  • Female
  • Humans
  • Psoriasis / complications
  • Psoriasis / drug therapy*

Substances

  • Anti-Asthmatic Agents
  • Antibodies, Monoclonal, Humanized
  • dupilumab
  • benralizumab
  • secukinumab