Koninginin W, a New Polyketide from the Endophytic Fungus Trichoderma koningiopsis YIM PH30002

Yong-Liang Wang; Bin-Yuan Hu; Meng-An Qian; Zi-Hang Wang; Jing-Mei Zou; Xu-Yan Sang; Lei Li; Xiao-Dong Luo; Li-Xing Zhao

doi:10.1002/cbdv.202100460

Koninginin W, a New Polyketide from the Endophytic Fungus Trichoderma koningiopsis YIM PH30002

Chem Biodivers. 2021 Sep;18(9):e2100460. doi: 10.1002/cbdv.202100460. Epub 2021 Aug 9.

Authors

Yong-Liang Wang^{1

2}, Bin-Yuan Hu¹, Meng-An Qian¹, Zi-Hang Wang¹, Jing-Mei Zou^{1

2}, Xu-Yan Sang^{1

2}, Lei Li^{1

2}, Xiao-Dong Luo¹, Li-Xing Zhao^{1

2}

Affiliations

¹ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research and Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
² Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091, P. R. China.

PMID: 34369658
DOI: 10.1002/cbdv.202100460

Abstract

A new compound named koninginin W (1) and four known polyketides (2-5) were isolated from endophytic fungus Trichoderma koningiopsis YIM PH30002 of Panax notoginseng. The structures of 1 - 5, including absolute configuration of 1, were elucidated on the detailed analysis of the HR-ESI-MS, 1D and 2D NMR, and X-ray crystallographic data. Koninginin W (1) presented weak antibacterial activity against Escherichia coli, Bacillus subtilis and Salmonella typhimurium.

Keywords: Trichoderma koningiopsis; antibacterial activity; polyketide.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Bacillus subtilis / drug effects*
Escherichia coli / drug effects*
Microbial Sensitivity Tests
Molecular Conformation
Salmonella typhimurium / drug effects*
Trichoderma / chemistry*

Substances

Anti-Bacterial Agents

Abstract

MeSH terms

Substances

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