N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses

Qianyu Feng; Hongwei Zhao; Lili Xu; Zhengde Xie

doi:10.3389/fcell.2021.699997

N6-Methyladenosine Modification and Its Regulation of Respiratory Viruses

Front Cell Dev Biol. 2021 Jul 23:9:699997. doi: 10.3389/fcell.2021.699997. eCollection 2021.

Authors

Qianyu Feng^{1

2}, Hongwei Zhao^{1

2}, Lili Xu^{1

2}, Zhengde Xie^{1

2}

Affiliations

¹ Beijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, National Key Discipline of Paediatrics (Capital Medical University), Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing Paediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.
² Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China.

Abstract

N6-methyladenosine (m⁶A) is a ubiquitous RNA modification in eukaryotes. It plays important roles in the translocation, stabilization and translation of mRNA. Many recent studies have shown that the dysregulation of m⁶A modification is connected with diseases caused by pathogenic viruses, and studies on the role of m⁶A in virus-host interactions have shown that m⁶A plays a wide range of regulatory roles in the life cycle of viruses. Respiratory viruses are common pathogens that can impose a large disease burden on young children and elderly people. Here, we review the effects of m⁶A modification on respiratory virus replication and life cycle and host immunity against viruses.

Keywords: N6-methyladenosine; RNA modification; adenovirus; human metapneumovirus; influenza A virus; respiratory syncytial virus.

Publication types

Review