A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging

Mingzhou Wu; Shuqing He; Xin Hu; Jingqin Chen; Enna Ha; Fujin Ai; Tao Ji; Junqing Hu; Shuangchen Ruan

doi:10.3389/fchem.2021.695511

A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging

Front Chem. 2021 Jul 22:9:695511. doi: 10.3389/fchem.2021.695511. eCollection 2021.

Authors

Mingzhou Wu^{1

2}, Shuqing He², Xin Hu², Jingqin Chen³, Enna Ha², Fujin Ai², Tao Ji², Junqing Hu², Shuangchen Ruan^{1

4}

Affiliations

¹ Shenzhen Key Laboratory of Laser Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China.
² College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
³ Research Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
⁴ Sino-German College of Intelligent Manufacturing, Shenzhen Technology University, Shenzhen, China.

Abstract

Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu_7.2S₄/5MoS₂ composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu_7.2S₄/5MoS₂ exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal-chemodynamic-photodynamic synergetic therapeutic effect in both in vitro and in vivo tests. Moreover, Cu_7.2S₄/5MoS₂ shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These results suggest a potential application of Cu_7.2S₄/5MoS₂ composite nanoflowers as photo/H₂O₂-responsive therapeutic agents against tumors.

Keywords: Cu7.2S4/5MoS2; composite nanoflowers; multimodal imaging; photothermal conversion efficiency; synergetic therapy.