A luminescent Zn-MOF exhibiting high water stability: selective detection of Cr(VI) ion and treatment activity on sepsis

Ying Wan; Xu-Mei Chen; Qian Zhang; Hong-Biao Jiang; Ran Feng

doi:10.1080/15685551.2021.1953239

A luminescent Zn-MOF exhibiting high water stability: selective detection of Cr(VI) ion and treatment activity on sepsis

Des Monomers Polym. 2021 Jul 27;24(1):216-223. doi: 10.1080/15685551.2021.1953239. eCollection 2021.

Authors

Ying Wan¹, Xu-Mei Chen¹, Qian Zhang², Hong-Biao Jiang¹, Ran Feng¹

Affiliations

¹ Emergency Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
² Department of Classical Chinese Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Abstract

A fresh metal-organic framework (MOF) based on the Zn ions as the metal ions has been prepared via the solvothermal method, and its chemical formula is [Zn(byia)(DMF)]·1.5DMF·7H₂O (1, byia = 5-(benzimidazol-2-yl) isophthalic acid). It is worth noting that the compound 1 has excellent water stability (which can be maintained in the water for at least a month). Most fascinating, in water, the compound 1 exhibits the strong blue luminescence, which can only be selectively quenched via the contaminant of the Cr₂O₇ ^2- ion. The selective luminescence quenching with low limits of detection and high values of K _sv proved its better sensing property, which can be compared with the contemporary materials. To development new strategy for the sepsis treatment, the biological activity and mechanism of the compound was explored. Firstly, the ELIA detection was performed in this experiment to assess the inhibition of compound against inflammatory factor storm during sepsis. Then, the inflammatory response in the immune cells was assessed by real time RT-PCR.

Keywords: Cr(VI) ion detection; MOF; inflammatory factor storm; sepsis treatment.