Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity

J Invest Dermatol. 2022 Feb;142(2):282-284. doi: 10.1016/j.jid.2021.06.016. Epub 2021 Aug 6.

Abstract

Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites.

Trial registration: ClinicalTrials.gov NCT03947450.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Fibroblasts / metabolism*
  • Foot
  • Hand
  • Humans
  • Keratin-9 / metabolism
  • Keratinocytes / metabolism*
  • Mice
  • Models, Animal
  • Skin / cytology
  • Skin / growth & development*
  • Skin / metabolism
  • Skin Pigmentation
  • Wnt Signaling Pathway

Substances

  • Keratin-9

Associated data

  • ClinicalTrials.gov/NCT03947450