Evidence from a meta-analysis for association of MC4R rs17782313 and FTO rs9939609 polymorphisms with susceptibility to obesity in children

Seyed Alireza Dastgheib; Reza Bahrami; Sepideh Setayesh; Seyedali Salari; Seyed Reza Mirjalili; Mahmood Noorishadkam; Jalal Sadeghizadeh-Yazdi; Elahe Akbarian; Hossein Neamatzadeh

doi:10.1016/j.dsx.2021.102234

Evidence from a meta-analysis for association of MC4R rs17782313 and FTO rs9939609 polymorphisms with susceptibility to obesity in children

Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102234. doi: 10.1016/j.dsx.2021.102234. Epub 2021 Jul 30.

Authors

Seyed Alireza Dastgheib¹, Reza Bahrami², Sepideh Setayesh³, Seyedali Salari⁴, Seyed Reza Mirjalili⁵, Mahmood Noorishadkam⁵, Jalal Sadeghizadeh-Yazdi⁶, Elahe Akbarian⁷, Hossein Neamatzadeh⁸

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
² Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: bahramir@sums.ac.ir.
³ School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴ Department of Biology, Science and Arts University, Yazd, Iran.
⁵ Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁶ Department of Food Science and Technology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁷ Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁸ Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

PMID: 34364300
DOI: 10.1016/j.dsx.2021.102234

Abstract

Background and aim: The aim of this study was to evaluate the association of MC4R rs17782313 and FTO rs9939609 polymorphisms with childhood obesity.

Methods: A universal search was performed up to May 2021.

Results: A total of 31 studies including 13 studies with 9565 cases and 11956 controls on MC4R rs17782313 and 18 studies with 4789 cases and 15918 controls on FTO rs9939609 were selected.

Conclusions: Pooled data showed that FTO rs9930506 and MC4R rs17782313 polymorphisms were significantly associated with obesity in children. Stratified analyses revealed that these genetic variants were associated with childhood obesity in Caucasian and Asian children.

Keywords: Children; Fat mass and obesity associated gene; Melanocortin-4 receptor gene; Obesity; Polymorphism.

Publication types

Meta-Analysis
Review

MeSH terms

Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics*
Child
Genetic Predisposition to Disease*
Humans
Pediatric Obesity / etiology
Pediatric Obesity / metabolism
Pediatric Obesity / pathology*
Polymorphism, Single Nucleotide*
Prognosis
Receptor, Melanocortin, Type 4 / genetics*

Substances

MC4R protein, human
Receptor, Melanocortin, Type 4
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
FTO protein, human