4,5,6,7-Tetrahydroindol-4-Ones as a Valuable Starting Point for the Synthesis of Polyheterocyclic Structures

Tomas Horsten; Wim Dehaen

doi:10.3390/molecules26154596

4,5,6,7-Tetrahydroindol-4-Ones as a Valuable Starting Point for the Synthesis of Polyheterocyclic Structures

Molecules. 2021 Jul 29;26(15):4596. doi: 10.3390/molecules26154596.

Authors

Tomas Horsten¹, Wim Dehaen¹

Affiliation

¹ Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.

Abstract

This review focuses on the synthesis of polyheterocyclic structures with a variety of medicinal and optoelectronic applications, starting from readily available 4,5,6,7-tetrahydroindol-4-one analogs. First, routes toward the 4,5,6,7-tetrahydroindol-4-one starting materials are summarized, followed by synthetic pathways towards polyheterocyclic structures which are categorized based on the size and attachment point of the newly formed (hetero)cyclic ring.

Keywords: biological activity; indolone; natural product; optoelectronics; polyheterocycle; pyrrole.

Publication types

Review

Grants and funding

G0F6619N/Fonds Wetenschappelijk Onderzoek