CD36 Signal Transduction in Metabolic Diseases: Novel Insights and Therapeutic Targeting

Cells. 2021 Jul 20;10(7):1833. doi: 10.3390/cells10071833.

Abstract

The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of cells and has multiple biological functions that may be important in inflammation and in the pathogenesis of metabolic diseases, including diabetes. Here, we consider recent insights into how the CD36 response becomes deregulated under metabolic conditions, as well as the therapeutic benefits of CD36 inhibition, which may provide clues for developing strategies aimed at the treatment or prevention of diabetes associated with metabolic diseases. To facilitate this process further, it is important to pinpoint regulatory mechanisms that are relevant under physiological and pathological conditions. In particular, understanding the mechanisms involved in dictating specific CD36 downstream cellular outcomes will aid in the discovery of potent compounds that target specific CD36 downstream signaling cascades.

Keywords: CD36 antigens; diabetes mellitus; inflammation; insulin-secreting cells; oxidative stress; reactive oxygen species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid / metabolism
  • Anti-Inflammatory Agents / therapeutic use
  • CD36 Antigens / antagonists & inhibitors
  • CD36 Antigens / genetics
  • CD36 Antigens / metabolism*
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / genetics
  • Diabetes Mellitus / metabolism*
  • Diabetes Mellitus / pathology
  • Fatty Acids / metabolism
  • Gene Expression Regulation
  • Humans
  • Hyperglycemia / drug therapy
  • Hyperglycemia / genetics
  • Hyperglycemia / metabolism*
  • Hyperglycemia / pathology
  • Inflammation
  • Insulin / metabolism
  • Insulin Receptor Substrate Proteins / genetics
  • Insulin Receptor Substrate Proteins / metabolism
  • Insulin Resistance
  • Insulin-Secreting Cells / drug effects
  • Insulin-Secreting Cells / metabolism*
  • Insulin-Secreting Cells / pathology
  • Lipoproteins, LDL / metabolism
  • Molecular Targeted Therapy
  • NF-kappa B / genetics
  • NF-kappa B / metabolism
  • Reactive Oxygen Species / antagonists & inhibitors
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction / genetics*

Substances

  • Amyloid
  • Anti-Inflammatory Agents
  • CD36 Antigens
  • CD36 protein, human
  • Fatty Acids
  • IRS1 protein, human
  • Insulin
  • Insulin Receptor Substrate Proteins
  • Lipoproteins, LDL
  • NF-kappa B
  • Reactive Oxygen Species
  • oxidized low density lipoprotein