Exercise for individuals with bone metastases: A systematic review

Sarah Weller; Nicolas H Hart; Kate A Bolam; Sami Mansfield; Daniel Santa Mina; Kerri M Winters-Stone; Anna Campbell; Friederike Rosenberger; Joachim Wiskemann; Morten Quist; Prue Cormie; Jennifer Goulart; Kristin L Campbell

doi:10.1016/j.critrevonc.2021.103433

Exercise for individuals with bone metastases: A systematic review

Crit Rev Oncol Hematol. 2021 Oct:166:103433. doi: 10.1016/j.critrevonc.2021.103433. Epub 2021 Aug 3.

Authors

Affiliations

¹ Provincial Programs, BC Cancer, 750 West Broadway, Vancouver, BC, V5Z 1H5, Canada. Electronic address: https://twitter.com/@_sarahweller.
² Cancer and Palliative Care Outcomes Centre, Queensland University of Technology, 191 Ipswich Rd, Woolloongabba, QLD, 4102, Australia; Exercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Institute for Health Research, University of Notre Dame Australia, 23 High Street, Freemantle, WA, 6160, Australia. Electronic address: https://twitter.com/@DrNicolasHart.
³ Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Fack 23400, SE-141 83 Huddinge, Stockholm, Sweden. Electronic address: https://twitter.com/@katebolam.
⁴ Cancer Wellness for Life, 8022 Reeder Street, Lenexa, KS, 66214, USA. Electronic address: https://twitter.com/@bewellwithsami.
⁵ Faculty of Kinesiology and Physical Education, University of Toronto, 27 King's College Cir, Toronto, Ontario, ON M5S, Canada. Electronic address: https://twitter.com/@DR_SantaMina.
⁶ Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA. Electronic address: https://twitter.com/@winters_stone.
⁷ Department of Sport, Exercise and Health & Science, School of Applied Sciences, Edinburgh Napier University, Sighthill Court, Edinburgh, EH11 4BN, UK. Electronic address: https://twitter.com/@CanRehab.
⁸ Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, Heidelberg, 69120, Germany.
⁹ Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, Heidelberg, 69120, Germany. Electronic address: https://twitter.com/@exoncolgermany.
¹⁰ The University Hospitals Centre for Health Research, Rigshospitalet, Blegdamsvej 9, 2100, København, Denmark. Electronic address: https://twitter.com/@QuistMorten.
¹¹ Mary MacKillop Institute for Health Research, Australian Catholic University, 5/215 Spring Street, Melbourne, VIC, 3000, Australia. Electronic address: https://twitter.com/@PrueCormie.
¹² Department of Radiation Oncology, BC Cancer, 2410 Lee Avenue, Victoria, BC, V8R 6V5, Canada.
¹³ Department of Physical Therapy, 212-2177 Wesbrook Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. Electronic address: Kristin.campbell@ubc.ca.

PMID: 34358650
DOI: 10.1016/j.critrevonc.2021.103433

Abstract

Background: Exercise has the potential to improve physical function and quality of life in individuals with bone metastases but is often avoided due to safety concerns. This systematic review summarizes the safety, feasibility and efficacy of exercise in controlled trials that include individuals with bone metastases.

Methods: MEDLINE, Embase, Pubmed, CINAHL, PEDro and CENTRAL databases were searched to July 16, 2020.

Results: A total of 17 trials were included incorporating aerobic exercise, resistance exercise or soccer interventions. Few (n = 4, 0.5%) serious adverse events were attributed to exercise participation, with none related to bone metastases. Mixed efficacy results were found, with exercise eliciting positive changes or no change. The majority of trials included an element of supervised exercise instruction (n = 16, 94%) and were delivered by qualified exercise professionals (n = 13, 76%).

Conclusions: Exercise appears safe and feasible for individuals with bone metastases when it includes an element of supervised exercise instruction.

Keywords: bone neoplasms; exercise; neoplasm metastasis; neoplasms; rehabilitation; sports; systematic review.

Publication types

Review
Systematic Review

MeSH terms

Bone Neoplasms* / therapy
Exercise
Exercise Therapy
Humans
Quality of Life*