First come, first served: Mammalian recombination is timed to replication

Jason A Halliwell; Eva R Hoffmann

doi:10.1016/j.cell.2021.07.014

First come, first served: Mammalian recombination is timed to replication

Cell. 2021 Aug 5;184(16):4112-4114. doi: 10.1016/j.cell.2021.07.014.

Authors

Jason A Halliwell¹, Eva R Hoffmann²

Affiliations

¹ DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
² DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: eva@sund.ku.dk.

PMID: 34358467
DOI: 10.1016/j.cell.2021.07.014

Abstract

Meiotic recombination drives the formation of new chromosomes in germ cells and is essential for fertility in mammals. In this issue of Cell, Pratto et al. have developed a method to map replication origins directly in mammalian tissue for the first time, revealing evolutionary conservation between replication timing and meiotic recombination in males.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Chromosomes
Germ Cells
Homologous Recombination
Male
Mammals* / genetics
Meiosis*