Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Eunmi Kim; Dong-Won Lee; Hae-Chul Park; Dong Hwee Kim

doi:10.1016/j.ymgmr.2021.100783

Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Mol Genet Metab Rep. 2021 Jul 21:28:100783. doi: 10.1016/j.ymgmr.2021.100783. eCollection 2021 Sep.

Authors

Eunmi Kim¹, Dong-Won Lee¹, Hae-Chul Park¹, Dong Hwee Kim²

Affiliations

¹ Department of Biomedical Sciences, College of Medicine, Korea University, Ansan 15355, Republic of Korea.
² Department of Physical Medicine and Rehabilitation, College of Medicine, Korea University, Ansan 15355, Republic of Korea.

Abstract

Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.

Keywords: ALA, alpha-lipoic acid; Alpha-lipoic acid; DM, diabetes mellitus; Diabetes mellitus; EM, embryo medium; HCs, hair cells; Hair cell; Pancreatic β-cell; Zebrafish.