A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles

Pezhman Shiri; Ali Mohammad Amani; Thomas Mayer-Gall

doi:10.3762/bjoc.17.114

A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles

Beilstein J Org Chem. 2021 Jul 13:17:1600-1628. doi: 10.3762/bjoc.17.114. eCollection 2021.

Authors

Pezhman Shiri^{1

2}, Ali Mohammad Amani^{1

2}, Thomas Mayer-Gall^{3

4}

Affiliations

¹ Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
² Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
³ Department of Physical Chemistry and Center of Nanointegration (CENIDE), University of Duisburg-Essen, Universitätsstr. 2, 45141 Essen, Germany.
⁴ Deutsches Textilforschungszentrum Nord-West gGmbH, Adlerstr. 1, 47798 Krefeld, Germany.

Abstract

Diverse strategies for the efficient and attractive synthesis of a wide variety of relevant 1,4,5-trisubstituted 1,2,3-triazole molecules are reported. The synthesis of this category of diverse fully functionalized 1,2,3-triazoles has become a necessary and unique research subject in modern synthetic organic key transformations in academia, pharmacy, and industry. The current review aims to cover a wide literature survey of numerous synthetic strategies. Recent reports (2017-2021) in the field of 1,4,5-trisubstituted 1,2,3-triazoles are emphasized in this current review.

Keywords: 1,4,5-trisubstituted 1,2,3-triazoles; Click reaction; N-containing heterocycles; [3 + 2]‐cycloaddition; azides; fully functionalized 1,2,3-triazoles.

Publication types

Review

Grants and funding

We gratefully appreciate the Shiraz University of Medical Sciences Research Councils for the financial support of this work.