The Term Newborn: Congenital Infections

Clin Perinatol. 2021 Aug;48(3):485-511. doi: 10.1016/j.clp.2021.05.004.

Abstract

Maternal pathogens can be transmitted to the fetus resulting in congenital infection with sequelae ranging from asymptomatic infection to severe debilitating disease and still birth. The TORCH pneumonic (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) is used widely, but it provides a limited description of the expanding list of pathogens associated with congenital infection. This article focuses on the evaluation and management of infants with common congenital infections such as cytomegalovirus, and infections that warrant early diagnosis and treatment to prevent serious complications, such as toxoplasmosis, human immunodeficiency virus, and syphilis. Zika virus and Chagas disease remain uncommon.

Keywords: Congenital; Infection; Newborn; Term.

Publication types

  • Review

MeSH terms

  • Female
  • Fetal Diseases*
  • Herpes Simplex* / diagnosis
  • Herpes Simplex* / drug therapy
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Complications, Infectious* / diagnosis
  • Pregnancy Complications, Infectious* / drug therapy
  • Pregnancy Complications, Infectious* / epidemiology
  • Rubella* / diagnosis
  • Syphilis*
  • Toxoplasmosis*
  • Toxoplasmosis, Congenital* / diagnosis
  • Toxoplasmosis, Congenital* / drug therapy
  • Toxoplasmosis, Congenital* / epidemiology
  • Zika Virus Infection* / diagnosis
  • Zika Virus Infection* / epidemiology
  • Zika Virus*