Studying Effects of Calcium Oxide Nanoparticles on Dentinogenesis in Male Wistar Rats

Bushra Habeeb Al-Maula; Zena Jehad Wally; Mohanad Jameel Najm Al-Magsoosi; Rasha Hatem Dosh; Ruba M Mustafa; Suhad Jabbar Hamed Al-Nasrawi; Abdullatif Alfutimie; Julfikar Haider

doi:10.1155/2021/9983538

Studying Effects of Calcium Oxide Nanoparticles on Dentinogenesis in Male Wistar Rats

Int J Dent. 2021 Jul 24:2021:9983538. doi: 10.1155/2021/9983538. eCollection 2021.

Authors

Bushra Habeeb Al-Maula¹, Zena Jehad Wally², Mohanad Jameel Najm Al-Magsoosi³, Rasha Hatem Dosh⁴, Ruba M Mustafa⁵, Suhad Jabbar Hamed Al-Nasrawi⁶, Abdullatif Alfutimie⁷, Julfikar Haider⁸

Affiliations

¹ Scientific Center of Laser and Photonics, University of Al-Hamdaniya, Ninvah, Iraq.
² Department of Prosthodontic, Faculty of Dentistry, University of Kufa, Najaf, Iraq.
³ Department of Oral Diagnosis, Faculty of Dentistry, University of Basrah, Basrah, Iraq.
⁴ Department of Anatomy and Histology, Faculty of Medicine, University of Kufa, Najaf, Iraq.
⁵ Department of Conservative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan.
⁶ Department of Conservative Dentistry, Faculty of Dentistry, University of Kufa, Kufa, Iraq.
⁷ School of Chemical Engineering and Analytical Sciences, University of Manchester, UK.
⁸ Department of Engineering, Manchester Metropolitan University, Manchester, UK.

Abstract

This study aimed to evaluate potential impacts of calcium oxide nanoparticles (CaO-NPs) at different dosages on predentin thickness, number of blood vessels, periodontal ligament thickness, and blood glucose level of Wistar rats. Twelve rats were randomly gathered into four groups, untreated (control) and CaO-NP-treated groups at three concentrations (25, 50, and 100 mg/kg of the body weight) over a period of 60 days. Histological investigation was performed on twenty-four lower incisor teeth extracted from all the tested groups under a light microscope, and an automatic Fujifilm was used to measure the blood glucose level. The results showed that regular nanoparticle treatment significantly increased predentin and periodontal ligament thicknesses, a gradual decrease in vascularization in the pulp tissue, and an increase in the blood glucose level as the dosages of nanoparticles administered to the rats increased. Administration of the CaO-NPs at low dosage (25 mg/kg) could be beneficial for the growth and integrity of teeth and dentinal tissues in rats.