A meta-analysis for association of TNF-α -308G>A polymorphism with susceptibility to Ankylosing Spondylitis

Masoud Mahdinejad-Yazdi; Mohammad Reza Sobhan; Seyed Alireza Dastgheib; Reza Bahrami; Seyed Hossein Shaker; Hamid Mirjalili; Jalal Sadeghizadeh-Yazdi; Masoud Zare-Shehneh; Hossein Neamatzadeh

doi:10.1016/j.jor.2021.07.015

A meta-analysis for association of TNF-α -308G>A polymorphism with susceptibility to Ankylosing Spondylitis

J Orthop. 2021 Jul 14:26:79-87. doi: 10.1016/j.jor.2021.07.015. eCollection 2021 Jul-Aug.

Authors

Masoud Mahdinejad-Yazdi¹, Mohammad Reza Sobhan¹, Seyed Alireza Dastgheib², Reza Bahrami³, Seyed Hossein Shaker⁴, Hamid Mirjalili⁵, Jalal Sadeghizadeh-Yazdi⁶, Masoud Zare-Shehneh⁷, Hossein Neamatzadeh^{7

8}

Affiliations

¹ Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
² Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
³ Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴ Department of Emergency Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁵ Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁶ Department of Food Science and Technology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁷ Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁸ Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract

Objective: We performed a meta-analysis of all eligible studies on the association of TNF-α -308G>A polymorphism with risk of Ankylosing spondylitis (AS).

Methods: A comprehensive literature research was performed in online databases.

Results: A total of 28 studies with 4489 cases and 5919 controls were included. Pooled ORs showed a significant association between TNF-α -308G>A polymorphism and risk of AS. Moreover, stratified analysis by ethnicity showed a significant association between TNF-α -308G>A polymorphism and AS risk in Asians, Caucasians and Mixed populations, but not in Chinese population.

Conclusion: This meta-analysis suggested that the TNF-α -308G>A polymorphism was associated with AS risk.

Keywords: Ankylosing spondylitis; Ethnicity; Joints inflammation; Meta-analysis; Polymorphism; TNF-α.

Publication types

Review