Transcriptomic profile of cationic channels in human pulmonary arterial hypertension

Abstract

The dysregulation of K⁺ channels is a hallmark of pulmonary arterial hypertension (PAH). Herein, the channelome was analyzed in lungs of patients with PAH in a public transcriptomic database. Sixty six (46%) mRNA encoding cationic channels were dysregulated in PAH with most of them downregulated (83%). The principal component analysis indicated that dysregulated cationic channel expression is a signature of the disease. Changes were very similar in idiopathic, connective tissue disease and congenital heart disease associated PAH. This analysis 1) is in agreement with the widely recognized pathophysiological role of TASK1 and K_V1.5, 2) supports previous preliminary reports pointing to the dysregulation of several K⁺ channels including the downregulation of K_V1.1, K_V1.4, K_V1.6, K_V7.1, K_V7.4, K_V9.3 and TWIK2 and the upregulation of K_Ca1.1 and 3) points to other cationic channels dysregulated such as Kv7.3, TALK2, Ca_V1 and TRPV4 which might play a pathophysiological role in PAH. The significance of other changes found in Na⁺ and TRP channels remains to be investigated.