Combined transcriptome and proteome profiling of SRC kinase activity in healthy and E527K defective megakaryocytes

Lore De Kock; Fabienne Ver Donck; Chantal Thys; Anouck Wijgaerts; Koji Eto; Chris Van Geet; Kathleen Freson

doi:10.3324/haematol.2021.279248

Combined transcriptome and proteome profiling of SRC kinase activity in healthy and E527K defective megakaryocytes

Haematologica. 2021 Dec 1;106(12):3206-3210. doi: 10.3324/haematol.2021.279248.

Authors

Lore De Kock¹, Fabienne Ver Donck¹, Chantal Thys¹, Anouck Wijgaerts¹, Koji Eto², Chris Van Geet¹, Kathleen Freson³

Affiliations

¹ Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, University of Leuven, Leuven.
² Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan; Department of Regenerative Medicine, Chiba University Graduate School of Medicine, Chiba.
³ Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, University of Leuven, Leuven. Kathleen.freson@kuleuven.be.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gene Expression Profiling
Humans
Megakaryocytes* / metabolism
Phosphorylation
Proteome*
Transcriptome
src-Family Kinases / genetics

Substances

Proteome
src-Family Kinases

Grants and funding

Funding: this work was supported by KULeuven BOF grant C14/19/096, FWO grant G072921N and research grants from Novo Nordisk and Swedish Orphan Biovitrum AB (SOBI).