Modulation of Aggregation-Caused Quenching to Aggregation-Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy

Cheng Wang; Ziyu Wang; Shaoqing Chen; Pengfei Cui; Lin Qiu; Shuwen Zhou; Hua Jiang; Pengju Jiang; Jianhao Wang

doi:10.1002/marc.202100264

Modulation of Aggregation-Caused Quenching to Aggregation-Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy

Macromol Rapid Commun. 2021 Oct;42(19):e2100264. doi: 10.1002/marc.202100264. Epub 2021 Aug 12.

Authors

Cheng Wang¹, Ziyu Wang², Shaoqing Chen³, Pengfei Cui¹, Lin Qiu¹, Shuwen Zhou¹, Hua Jiang⁴, Pengju Jiang¹, Jianhao Wang¹

Affiliations

¹ School of Pharmacy, Changzhou University, Changzhou, Jiangsu, 213164, China.
² State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, 199 Ren'ai Road, Suzhou, 215123, P. R. China.
³ College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, P. R. China.
⁴ Department of Oncology, Second People's Hospital of Changzhou, Nanjing Medical University, Changzhou, 213003, P. R. China.

PMID: 34347315
DOI: 10.1002/marc.202100264

Abstract

Dual intramolecular FRET polymers are synthesized via Suzuki coupling and their luminescence characteristics from aggregation-caused quenching (ACQ) to aggregation-induced emission (AIE) is modulated conveniently by adjusting the charged ratios. The finally obtained AIE polymer is further employed to construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy.

Keywords: aggregation-caused quenching; aggregation-induced emission; cancer therapy; fluorescence resonance energy transfer; theranostics.

MeSH terms

Humans
Nanoparticles*
Neoplasms* / drug therapy
Polymers
Precision Medicine
Theranostic Nanomedicine

Substances

Polymers

Abstract

MeSH terms

Substances

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