Bioavailability comparison between a compound comprising hesperetin-7-glucoside with β-cyclodextrin and a mixture of hesperidin and dextrin in healthy adult human males

Abstract

The pharmacokinetics of compounds comprising hesperetin-7-glucoside with β-cyclodextrin and physically mixed hesperidin/dextrin was compared in 8 healthy adult male subjects in a nonrandomized, double-blind, cross-over, controlled study. For 0-24 h, the area under the curve of the total plasma hesperetin concentration after hesperetin-7-glucoside with β-cyclodextrin consumption was >100-fold higher than that after hesperidin/dextrin consumption.

Keywords: β-cyclodextrin; bioavailability; hesperetin-7-glucoside; inclusion complex.