Decoding m6A mRNA methylation by reader proteins in cancer

Abstract

N⁶-methyladenosine (m⁶A), the most prevalent internal modification in eukaryotic mRNAs, regulates gene expression at the post-transcriptional level. The reader proteins of m⁶A, mainly YTH domain-containing proteins, specifically recognize m⁶A-modified mRNAs and regulate their metabolism. Recent studies have highlighted essential roles of m⁶A readers in the initiation and development of human cancers. In this review, we summarize recent findings about the biological functions of YTH domain proteins in cancers, the underlying mechanisms, and clinical implications. Gene expression reprogramming by dysregulated m⁶A reader proteins offers potential targets for cancer treatment, while targeted m⁶A editors and readers provide tools to manipulate m⁶A metabolism in cancers.

Keywords: Cancer; YTH domain protein; m(6)A editor; m(6)A modification; mRNA metabolism.