The Pathogenic Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Possible Mechanisms for Immune Evasion?

Zhihui Wang; Ming Zhou; Zhenfang Fu; Ling Zhao

doi:10.3389/fimmu.2021.693579

The Pathogenic Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Possible Mechanisms for Immune Evasion?

Front Immunol. 2021 Jul 14:12:693579. doi: 10.3389/fimmu.2021.693579. eCollection 2021.

Authors

Zhihui Wang¹, Ming Zhou^{1

2}, Zhenfang Fu¹, Ling Zhao^{1

2}

Affiliations

¹ State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
² Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Abstract

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a newly emerging, highly transmitted and pathogenic coronavirus that has caused global public health events and economic crises. As of March 4, 2021, more than 100 million people have been infected, more than 2 million deaths have been reported worldwide, and the numbers are continuing to rise. To date, a specific drug for this lethal virus has not been developed to date, and very little is currently known about the immune evasion mechanisms of SARS-CoV-2. The aim of this review was to summarize and sort dozens of published studies on PubMed to explore the pathogenic features of SARS-CoV-2, as well as the possible immune escape mechanisms of this virus.

Keywords: S protein; SARS-CoV-2; epidemiology; immune escape; interaction; pathogenic features.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
COVID-19 / epidemiology
COVID-19 / immunology*
Host-Pathogen Interactions
Humans
Immune Evasion
Pandemics
SARS-CoV-2 / physiology*
Severe Acute Respiratory Syndrome / immunology*