Role of Hydrogen Sulfide in the Endocrine System

Abstract

Hydrogen sulfide (H₂S), as one of the three known gaseous signal transduction molecules in organisms, has attracted a surging amount of attention. H₂S is involved in a variety of physiological and pathological processes in the body, such as dilating blood vessels (regulating blood pressure), protecting tissue from ischemia-reperfusion injury, anti-inflammation, carcinogenesis, or inhibition of cancer, as well as acting on the hypothalamus and pancreas to regulate hormonal metabolism. The change of H₂S concentration is related to a variety of endocrine disorders, and the change of hormone concentration also affects the synthesis of H₂S. Understanding the effect of biosynthesis and the concentration of H₂S on the endocrine system is useful to develop drugs for the treatment of hypertension, diabetes, and other diseases.

Keywords: endocrine system; hormone; hydrogen sulfide; hypothalamus; pancreas.