Changes in Resting-State Spontaneous Brain Activity in Patients With Allergic Rhinitis: A Pilot Neuroimaging Study

Ziang Gao; Xixiang Chen; Rong Xiang; Wei Zhang; Lu Tan; Wenjun Fan; Peiqiang Liu; Hao Lv; Yu Xu

doi:10.3389/fnins.2021.697299

Changes in Resting-State Spontaneous Brain Activity in Patients With Allergic Rhinitis: A Pilot Neuroimaging Study

Front Neurosci. 2021 Jul 14:15:697299. doi: 10.3389/fnins.2021.697299. eCollection 2021.

Authors

Ziang Gao¹, Xixiang Chen², Rong Xiang¹, Wei Zhang¹, Lu Tan¹, Wenjun Fan¹, Peiqiang Liu¹, Hao Lv¹, Yu Xu¹

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
² Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China.

Abstract

Background: Allergic rhinitis (AR) is an inflammatory disorder of the nose caused by immunoglobulin E (IgE)-mediated immune response to allergens. Apart from the typical symptoms of sneezing, itching, rhinorrhea, and nasal congestion, behavioral complications were also reported to be associated with the progression of AR, such as cognitive deficits, mood changes, memory decline, attention deficiency, poor school performance, anxiety, and depression. Recent human studies have suggested that alterations in brain function caused by allergen exposure may precipitate high levels of anxiety and emotional reactivity in asthma patients. But until now, there is no direct evidence of the relationship between brain activity and allergic rhinitis.

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) was used to excavate whether there remain functional changes of brain activity in AR patients. We measured the amplitude of low-frequency fluctuation (ALFF) and the z conversion of ALFF (zALFF) in 20 patients with AR and 20 age- and sex-matched healthy controls (HCs) using the rs-fMRI data.

Results: Compared with healthy controls, AR patients exhibited lower ALFF values in the precuneus (PCUN) and higher ALFF values in the anterior cingulate cortex (ACC). The ALFF values of these features were significantly correlated with the visual analog scale (VAS) scores, the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores, the subscales of RQLQ, and specific IgE, partly.

Conclusion: We found changes in resting-state spontaneous brain activity in AR patients with hypoactivity in the PCUN and hyperactivity of the ACC. The brain-related symptoms of AR might be another potential clinical intervention target for improving the life quality of AR patients. Further attention to brain activity is essential for a deeper understanding of AR.

Keywords: allergic rhinitis; anterior cingulate cortex; cognition; memory; neuroimaging; precuneus; resting-state fMRI.