Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults

Fatema Al-Rashed; Sardar Sindhu; Ashraf Al Madhoun; Abdulwahab Alghaith; Rafaat Azim; Fahd Al-Mulla; Rasheed Ahmad

doi:10.2147/NSS.S311415

Short Sleep Duration and Its Association with Obesity and Other Metabolic Risk Factors in Kuwaiti Urban Adults

Nat Sci Sleep. 2021 Jul 24:13:1225-1241. doi: 10.2147/NSS.S311415. eCollection 2021.

Authors

Fatema Al-Rashed¹, Sardar Sindhu², Ashraf Al Madhoun^{2

3}, Abdulwahab Alghaith⁴, Rafaat Azim¹, Fahd Al-Mulla³, Rasheed Ahmad¹

Affiliations

¹ Immunology & Microbiology Department, Dasman Diabetes Institute, Dasman, Kuwait.
² Animal and Imaging Core Facility, Dasman Diabetes Institute, Dasman, Kuwait.
³ Genetics and Bioinformatics Department, Dasman Diabetes Institute, Dasman, Kuwait.
⁴ Royal College of Surgeons in Ireland, Dublin, Ireland.

Abstract

Background: Efficient sleep duration and its quality are increasingly recognized as important contributors for maintaining normal body weight. However, lifestyle and social structure within the Arab-gulf region differ compared to those in the western world. This study was specifically conducted in Kuwait's population to investigate the link between sleep quality (SQ) and obesity in the absence of sleep apnea (SA) onset.

Methods: SQ was measured by the Pittsburgh Sleep Quality Index (PQSI) in 984 participants, then verified in 60 individuals including 20 lean (Body mass index/BMI: 18.5-24.9 kg/m²), 20 overweight (BMI: 25-29.9 kg/m²) and 20 obese (BMI: ≥30 kg/m²) through actigraph worn over the right-hip for 7 consecutive days to characterize their sleep-wake cycle, rest-activity, and physical activity. Blood samples were collected for metabolic markers.

Results: 59.6% of participants reported a PSQI score higher than 5, with 57.6% of the participants reporting less than 6 hours of sleep per day. The data show that both SQ and sleep duration are considered inadequate in comparison to the international SQ standards. We found a significant association between SQ and obesity independent of age and sex. Actigraph data further supported the independent association of sleep duration on BMI within the population (p < 0.001). Additionally, total sleep time (TST) was found to significantly correlate with several other metabolic factors including diastolic blood pressure, elevated resting heart rate (RHR), triglycerides, total cholesterol, homeostatic model assessment for insulin resistance (HOMA-IR), C-peptide, and C-Reactive Protein (CRP) secretion. Further multiple-regression analysis showed a significant independent association between blood pressure (p < 0.03), HOMA-IR (p < 0.04), and C-peptide (p < 0.3) and sleep duration.

Conclusion: These findings suggest that sleep deprivation and disturbance could be indirect factors involved in the development of not only obesity in Kuwait but also other metabolic syndromes such as type 2 diabetes.

Keywords: Kuwait; PSQI; obesity; sleep.

Grants and funding

This work was supported by grants (RH HM-2019-019) from Kuwait Foundation for the Advancement of Sciences (KFAS).