Cyclohexane-angularly-fused triquinanes, 6-5-5-5 tetracycles, have attracted the attention of synthetic chemists due to their highly congested core structures and multiple quaternary carbon centers. This review focuses on the six completed total synthesis of naturally occurring cyclohexane-angularly-fused triquinanes in addition to seven notable methodologies that have been developed for the synthesis of these structures.
Keywords: 6-5-5-5 tetracycles; cyclohexane-angularly-fused triquinane; cyclopianes; natural products; total synthesis; waihoensene.