Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling

Hypertension. 2021 Sep;78(3):647-660. doi: 10.1161/HYPERTENSIONAHA.121.17177. Epub 2021 Aug 2.

Abstract

[Figure: see text].

Keywords: calcineurin; calpain; fibrosis; homeostasis; mechanotransduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Agonists / pharmacology
  • Animals
  • Calcineurin / metabolism*
  • Calcium / metabolism*
  • Calcium Signaling / drug effects
  • Calcium Signaling / genetics
  • Calpain / metabolism*
  • Cardiomegaly / genetics
  • Cardiomegaly / metabolism*
  • Homeostasis / drug effects
  • Homeostasis / physiology
  • Ion Channels / genetics
  • Ion Channels / metabolism*
  • Isoproterenol / pharmacology
  • Mechanotransduction, Cellular / physiology*
  • Mice
  • Mice, Knockout
  • Myocytes, Cardiac / drug effects
  • Myocytes, Cardiac / metabolism
  • Pyrazines / pharmacology
  • Rats
  • Thiadiazoles / pharmacology

Substances

  • Adrenergic beta-Agonists
  • Ion Channels
  • Piezo1 protein, mouse
  • Pyrazines
  • Thiadiazoles
  • yoda-1
  • Calcineurin
  • Calpain
  • Isoproterenol
  • Calcium