15-Deoxy-Δ-12,14-prostaglandin J2 effects in vascular smooth muscle cells: Implications in vascular smooth muscle cell proliferation and contractility

Carl Eguez; Michelle A Clark; Ann Tenneil O'Connor

doi:10.1016/j.prostaglandins.2021.106583

15-Deoxy-Δ-^12,14-prostaglandin J2 effects in vascular smooth muscle cells: Implications in vascular smooth muscle cell proliferation and contractility

Prostaglandins Other Lipid Mediat. 2021 Oct:156:106583. doi: 10.1016/j.prostaglandins.2021.106583. Epub 2021 Jul 29.

Authors

Carl Eguez¹, Michelle A Clark², Ann Tenneil O'Connor³

Affiliations

¹ Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA. Electronic address: ce668@mynsu.nova.edu.
² Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA(1). Electronic address: miclark@nova.edu.
³ Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA(1). Electronic address: ao594@nova.edu.

PMID: 34332056
DOI: 10.1016/j.prostaglandins.2021.106583

Abstract

15-Deoxy-Δ-^12,14-prostaglandin J2 (15d-PGJ2) is an endogenous agonist of the ligand dependent transcriptional factor, peroxisome proliferator-activated receptor -gamma (PPAR-γ). Although PPAR-γ mediates some actions of 15d-PGJ2, many actions of 15d-PGJ2 are independent of PPAR-γ. The PPAR-γ signaling pathway has beneficial effects on tumor progression, inflammation, oxidative stress, and angiogenesis in numerous studies. In this review, various studies were analyzed to understand the effects of 15d-PGJ2 in vascular smooth muscle cells (VSMC)s. 15d-PGJ2 inhibits proliferation of VSMCs during vascular remodeling and it alters the expression of contractile proteins and inflammatory components within these cells as well. However, the effects of 15d-PGJ2 as well as its ability to induce PPAR-γ activation remains controversial as contradictory effects of this prostaglandin in VSMCs exist. Understanding the mechanisms by which 15d-PGJ2 elicit beneficial actions whether by PPAR-γ activation or independently, will aid in developing new therapeutic strategies for diseases such as hypertension with an inflammatory component. Although great advances are being made, more research is needed to reach definitive conclusions.

Keywords: 15d-PGJ2; PPAR-γ; VSMC; VSMC proliferation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Prostaglandin D2 / analogs & derivatives*

Substances

9-deoxy-delta-9-prostaglandin D2
Prostaglandin D2