Autophagy balances the zinc-iron seesaw caused by Zn-stress

Daiki Shinozaki; Kohki Yoshimoto

doi:10.1016/j.tplants.2021.06.014

Autophagy balances the zinc-iron seesaw caused by Zn-stress

Trends Plant Sci. 2021 Sep;26(9):882-884. doi: 10.1016/j.tplants.2021.06.014. Epub 2021 Jul 27.

Authors

Daiki Shinozaki¹, Kohki Yoshimoto²

Affiliations

¹ Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan; Life Sciences Program, Graduate School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan; Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan.
² Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan; Life Sciences Program, Graduate School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan. Electronic address: kohki_yoshimoto@meiji.ac.jp.

PMID: 34330656
DOI: 10.1016/j.tplants.2021.06.014

Abstract

Under zinc (Zn) deficiency, plants take up excess iron (Fe), but the uptake is inhibited under Zn excess. Coordination between intracellular recycling, transport, and sensing is essential for Zn-Fe homeostasis. A new study shows that autophagy resupplies Zn²⁺ and Fe²⁺ to correct intracellular Zn-Fe imbalances.

Keywords: Arabidopsis thaliana; autophagy; iron; metal homeostasis; zinc.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arabidopsis* / metabolism
Autophagy
Gene Expression Regulation, Plant
Iron / metabolism
Zinc* / metabolism

Substances

Iron
Zinc