Fine-tuning ALK1 linear polyubiquitination to control angiogenesis

Peter Ten Dijke; David Baker

doi:10.1016/j.tcb.2021.07.004

Fine-tuning ALK1 linear polyubiquitination to control angiogenesis

Trends Cell Biol. 2021 Sep;31(9):705-707. doi: 10.1016/j.tcb.2021.07.004. Epub 2021 Jul 27.

Authors

Peter Ten Dijke¹, David Baker²

Affiliations

¹ Oncode Institute and Cell Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: P.ten_dijke@lumc.nl.
² Oncode Institute and Cell Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 34330579
DOI: 10.1016/j.tcb.2021.07.004

Abstract

Editing linear polyubiquitination of protein substrates by LUBAC and OTULIN is known to play a critical role in immune responses. A recent study by Fu et al. reveals how reversible linear polyubiquitination of the activin receptor-like kinase (ALK1) controls developmental angiogenesis and how its dysfunction leads to vascular malformations in humans.

Keywords: ALK1; BMP9; LUBAC; OTULIN; angiogenesis; arteriovenous malformation.

MeSH terms

Activin Receptors, Type II* / genetics
Activin Receptors, Type II* / metabolism
Humans
Neovascularization, Pathologic
Signal Transduction*
Ubiquitination

Substances

Activin Receptors, Type II