Pulmonary rehabilitation outcomes in individuals with chronic obstructive pulmonary disease: A systematic review

Sara Souto-Miranda; Guilherme Rodrigues; Martijn A Spruit; Alda Marques

doi:10.1016/j.rehab.2021.101564

Pulmonary rehabilitation outcomes in individuals with chronic obstructive pulmonary disease: A systematic review

Ann Phys Rehabil Med. 2022 May;65(3):101564. doi: 10.1016/j.rehab.2021.101564. Epub 2021 Nov 15.

Authors

Sara Souto-Miranda¹, Guilherme Rodrigues², Martijn A Spruit³, Alda Marques⁴

Affiliations

¹ Lab3R - Respiratory Research and Rehabilitation Laboratory, School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal; iBiMED: Institute of Biomedicine, University of Aveiro, Aveiro, Portugal; Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands.
² Lab3R - Respiratory Research and Rehabilitation Laboratory, School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal.
³ Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands; Department of Research and Development, CIRO, Horn, Netherlands.
⁴ Lab3R - Respiratory Research and Rehabilitation Laboratory, School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal; iBiMED: Institute of Biomedicine, University of Aveiro, Aveiro, Portugal. Electronic address: amarques@ua.pt.

PMID: 34329794
DOI: 10.1016/j.rehab.2021.101564

Abstract

Background: The magnitude of response to pulmonary rehabilitation (PR) is influenced by the selection of outcomes and measures.

Objectives: This systematic review aimed to review all outcomes and measures used in clinical trials of PR for individuals with chronic obstructive pulmonary disease (COPD).

Methods: The review involved a search of Scopus, Web of Knowledge, Cochrane Library, EBSCO, Science Direct and PubMed databases for studies of stable individuals with COPD undergoing PR. Frequency of reporting for each domain, outcome and measure was synthesized by using Microsoft Excel.

Results: We included 267 studies (43153 individuals with COPD). A broad range of domains (n = 22), outcomes (n = 163) and measures (n = 217) were reported. Several measures were used for the same outcome. The most reported outcomes were exercise capacity (n = 218) assessed with the 6-min walk test (n = 140), health-related quality of life (n = 204) assessed with the Saint George's respiratory questionnaire (n = 99), and symptoms (n = 158) assessed with the modified Medical Research Council dyspnoea scale (n = 56). The least reported outcomes were comorbidities, adverse events and knowledge.

Conclusions: This systematic review reinforces the need for a core outcome set for PR in individuals with COPD because of high heterogeneity in reported outcomes and measures. Future studies should assess the importance of each outcome for PR involving different stakeholders.

Prospero id: CRD42017079935.

Keywords: COPD; Core outcome set; Pulmonary rehabilitation.

Publication types

Review
Systematic Review

MeSH terms

Humans
Lung
Pulmonary Disease, Chronic Obstructive*
Quality of Life*
Treatment Outcome
Walk Test