Synthesis of Indolo[2,1- a]benzazepinones through Rhodium-Catalyzed Cascade Reactions of 2-Arylindoles with Allyl Alcohols

Org Lett. 2021 Aug 20;23(16):6272-6277. doi: 10.1021/acs.orglett.1c02064. Epub 2021 Jul 30.

Abstract

An efficient synthesis of indolo[2,1-a]benzazepinones through rhodium-catalyzed cascade reactions of 2-arylindoles with allyl alcohols has been developed. This work expands the scope of products that are available through C-H activation/intramolecular annulation reactions of 2-arylindoles in organic synthesis.