Medical and aesthetic improvement of photodamaged skin by the combination of intense pulsed light and photodynamic therapy with 10% aminolevulinic acid hydrochloride gel

Lasers Surg Med. 2022 Jan;54(1):62-65. doi: 10.1002/lsm.23460. Epub 2021 Jul 29.

Abstract

Objective: To evaluate the efficacy and safety of photodynamic therapy (PDT) with the novel 10% aminolevulinic acid (ALA) hydrochloride gel (10% ALA gel) and BF-RhodoLED® light (635 nm; 37 J/cm2 ) in combination with intense pulsed light (IPL) to augment the medical and aesthetic improvement of photodamaged skin of the décolleté.

Methods: This was a single-site prospective, randomized, intraindividual split chest pilot study with 20 female subjects with moderate to severe photodamage of the décolleté. Subjects were randomized to ALA-PDT + IPL to one split-side of the chest and ALA-PDT only to the contralateral side. Three blinded raters assessed aesthetic improvement using the global aesthetic improvement scale (GAIS).

Results: Eighteen subjects completed the study. Superior GAIS results were achieved on the ALA-PDT + IPL treatment side than on the ALA-PDT only treatment side (p < 0.001) after 24 weeks of follow-up.

Conclusions: ALA-PDT using 10% ALA hydrochloride gel and BF-RhodoLED® light had superior rejuvenation effects on the décolleté when combined with IPL compared to ALA-PDT alone.

Keywords: Ameluz; BF-RhodoLED; IPL; Tph; aminolevulinic acid; chest; décolletéIP; otodamageph; otodynamic therapyre; rejuvenation.

Publication types

  • Case Reports
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminolevulinic Acid* / therapeutic use
  • Esthetics
  • Female
  • Humans
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use
  • Pilot Projects
  • Prospective Studies
  • Treatment Outcome

Substances

  • Photosensitizing Agents
  • Aminolevulinic Acid