Homo/Heteropentanuclear Porphyrazine MgII, ZnII, and PdII Macrocycles with Externally Pending PdCl2 and Pd(CBT)2 Units: Synthesis, Physicochemical Characterization, and Photoactivity Studies

Noemi Bellucci; Maria Pia Donzello; Elisa Viola; Claudio Ercolani

doi:10.1021/acs.inorgchem.1c01195

Homo/Heteropentanuclear Porphyrazine Mg^II, Zn^II, and Pd^II Macrocycles with Externally Pending PdCl₂ and Pd(CBT)₂ Units: Synthesis, Physicochemical Characterization, and Photoactivity Studies

Inorg Chem. 2021 Aug 16;60(16):12029-12038. doi: 10.1021/acs.inorgchem.1c01195. Epub 2021 Jul 29.

Authors

Noemi Bellucci¹, Maria Pia Donzello¹, Elisa Viola¹, Claudio Ercolani¹

Affiliation

¹ Dipartimento di Chimica, Università degli Studi di Roma Sapienza, P. le A. Moro 5, I-00185 Rome, Italy.

PMID: 34324342
DOI: 10.1021/acs.inorgchem.1c01195

Abstract

Recent work has been developed on two new classes of neutral porphyrazine complexes of formulas [(PdCl₂)₄Py₈PzM]·xH₂O (Py₈Pz = octakis(2-pyridyl)porphyrazinato anion; M = Mg^II(H₂O), Zn^II, Pd^II) and [{Pd(CBT)₂}₄Py₈PzM]·xH₂O (M = Mg^II(H₂O), Zn^II; CBT = m-carborane-1-thiolate anion). Characterization of all the species has been conducted by IR and UV-visible spectral measurements in a systematic comparison with the corresponding already known mononuclear species [Py₈PzM] (M = Mg^II(H₂O), Zn^II) and the mono-Pd^II analogue isolated and presented here for the first time. Comparison includes also the two parent classes of pentanuclear tetrapyrazinoporphyrazines having the more extended π-electron delocalized macrocyclic core Py₈TPyzPz. The reported new classes of pentanuclear complexes behave as active photosensitizers in photodynamic therapy (PDT), and due to the high boron content of the CBT derivatives, perspectives for them are open of application in the field of bimodal PDT/BNCT (boron neutron capture therapy) anticancer treatments.