Integrated single-cell RNA sequencing analyses suggest developmental paths of cancer-associated fibroblasts with gene expression dynamics

Hee Chul Chung; Eun Jeong Cho; Hyeonjin Lee; Won-Kyung Kim; Ji-Hye Oh; Seok-Hyung Kim; Dakeun Lee; Chang Ohk Sung

doi:10.1002/ctm2.487

Integrated single-cell RNA sequencing analyses suggest developmental paths of cancer-associated fibroblasts with gene expression dynamics

Clin Transl Med. 2021 Jul;11(7):e487. doi: 10.1002/ctm2.487.

Authors

Hee Chul Chung^{1

2}, Eun Jeong Cho^{1

3}, Hyeonjin Lee^{1

2}, Won-Kyung Kim^{1

3}, Ji-Hye Oh^{1

3}, Seok-Hyung Kim⁴, Dakeun Lee⁵, Chang Ohk Sung^{1

2

3}

Affiliations

¹ Center for Cancer Genome Discovery, Asan Institute for Life Sciences, Asan Medical Center, Songpa-gu, Seoul, Republic of Korea.
² Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea.
³ Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
⁴ Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
⁵ Department of Pathology, Ajou University School of Medicine, Suwon, Republic of Korea.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cancer-Associated Fibroblasts / cytology
Cancer-Associated Fibroblasts / metabolism*
Gene Expression Regulation*
Homeodomain Proteins / genetics
Homeodomain Proteins / metabolism
Humans
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / metabolism
Neoplasms / metabolism
Neoplasms / pathology
Principal Component Analysis
Sequence Analysis, RNA
Single-Cell Analysis

Substances

Homeodomain Proteins
PRRX1 protein, human