Acute Myocardial Dysfunction and Hypereosinophilic Infiltrative Myocarditis Secondary to New-Onset Pediatric Acute Lymphoblastic Leukemia

Vanessa N Ogueri; Joshua R Mellor; Nivedita Muralidhar; Rebecca MacDonell-Yilmaz; Jennifer J G Welch; Brett W Goudie; Saurabh Agarwal; Ranna A Rozenfeld

doi:10.1016/j.jaccas.2021.03.017

Acute Myocardial Dysfunction and Hypereosinophilic Infiltrative Myocarditis Secondary to New-Onset Pediatric Acute Lymphoblastic Leukemia

JACC Case Rep. 2021 Jul 7;3(7):991-996. doi: 10.1016/j.jaccas.2021.03.017.

Authors

Vanessa N Ogueri¹, Joshua R Mellor¹, Nivedita Muralidhar¹, Rebecca MacDonell-Yilmaz^{1

2}, Jennifer J G Welch^{1

2}, Brett W Goudie^{1

3}, Saurabh Agarwal⁴, Ranna A Rozenfeld^{1

5}

Affiliations

¹ Department of Pediatrics, Hasbro Children's Hospital, Providence, Rhode Island, USA.
² Division of Hematology/Oncology, Department of Pediatrics, Hasbro Children's Hospital, Providence, Rhode Island, USA.
³ Division of Cardiology, Department of Pediatrics, Hasbro Children's Hospital, Providence, Rhode Island, USA.
⁴ Division of Cardiothoracic Imaging, Department of Diagnostic Imaging, Rhode Island Hospital, Providence Rhode Island, USA.
⁵ Division of Critical Care Medicine, Department of Pediatrics, Hasbro Children's Hospital, Providence, Rhode Island, USA.

Abstract

Myocardial infiltration by eosinophils leads to myocardial inflammation and fibrosis, resulting in restrictive hemodynamics. We describe an uncommon presentation of eosinophilic predominant acute lymphoblastic leukemia that manifested with hypereosinophilic infiltrative myocarditis. (Level of Difficulty: Advanced.).

Keywords: ALL, acute lymphoblastic leukemia; CMR, cardiac magnetic resonance; CT, computed tomography; EF, ejection fraction; HD, hospital day; LV, left ventricular; acute lymphoblastic leukemia; eosinophilia; myocarditis; pediatric.

Publication types

Case Reports